Langerhance Cell Histiocytosis with Primary Cutaneous and Oral Manifestations

 

Abstract
Introduction: Histiocytosis of lagerhans cell is a spectrum of disorders characterized by proliferation of Histiocyte like cells and includes following: Eosinophilic granuloma, Hand - Schuller Christian disease and Letterer- Siwe disease. The incidence is 0/5 in 100/000 person per year in individuals younger than 15 year of age.
Case Report: The patient was a 57 day old male infant that was referred with papulovesicular cutaneous and exophitic oral lesions without bone and visceral involvement. Diagnostic procedures until final diagnosis of Langerhance cell Histiocytosis and treatment of this case have been reported.
Conclusion: oral lesions could be the first manifestation of disease and dentists should be aware of that. According to different investigations, the disease may have a genetic basis.
Key words: Langerhance cell, Histiocytosis, papulovisicular, oral mucosa