Document Type : Original Articles

Abstract

Introduction: There is limited research available on neo-angiogenesis in dysplastic lesions. Since CD105 is expressed as a marker for neo-angiogenesis, this study was undertaken to compare CD105 expression between normal and dysplastic oral mucosa.Materials & Methods: In this descriptive cross-sectional study, 20 paraffin blocks were selected from dysplastic oral lesions of patients, based on histopathological criteria, during past 10 years in the Department of Oral and Maxillofacial Pathology of School of Dentistry, using simple sampling techniques. In addition, 20 samples were taken from the normal mucosa of patients referring for implant surgery or wisdom tooth surgery after informed consent. The samples were stained immunohisto-chemically for CD105 marker and evaluated by two pathologists simultaneously under a light microscope at ×400. The mean of stained areas was calculated as mean vessel density in each sample. Data were analyzed with Mann-Whitney test (α=0.05).Results: Means of CD105 marker expression in the dysplastic and normal groups were 7.58±6.19 and 0±0, respectively, with significant differences between the two groups (p value < 0.001).Conclusion: Considering the absence of CD105 marker in normal mucosa and significant expression of it in the dysplastic group, it can be concluded that dysplasia is accompanied by neo-angiogenesis and CD105 marker can be a good marker for detecting dysplastic changes.Key words: Dysplastic lesions,Malignancy, Oral mucosa.