A review on threatening effects of GM-CSF recombinant protein (Molgramostim drug)

Document Type : مقاله‌های مروری

Authors

1 Associate Professor, Dental Research Center, Department of Oral and Maxillofacial Medicine, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.

2 Assistant professor, Dental Research Center, Department of Oral and Maxillofacial Medicine, School of Dentistry, Isfahan University of Medical Sciences , Isfahan, Iran.

3 Dental Student, Dental Students Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.

4 M.S, Young Researchers and Elite Club, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran.

10.48305/v12i4.1287

Abstract

Introduction: Synthesis of new drugs, including GM-CSF (granulocyte-macrophage colony-stimulating factor), is one of the most important use of recombinant DNA technology. GM-CSF is a Molgramostim drug that is widely used in order to reduce the side effects of chemotherapy and enhance the immune system. Treatment of dental abscesses in patients undergoing chemotherapy is one of the most common uses of this drug in dentistry. In addition, GM-CSF has a key role in the treatment of mucositis in patients undergoing chemotherapy and radiotherapy of the oral area. In this review, the different uses of the recombinant molgramostim drugs in treating different diseases were evaluated.
Article Explanation: In the current review paper, relevant articles were collected from ISI Web of Science and PubMed databases by using Google Scholar search engine from 1973 to 2014. The articles were analyzed for 8 months. Articles related to the effect of recombinant GM-CSF on treating disease were included in the current paper.
Conclusion: The potency of GM-CSF in inducing the production of granulocytes and macrophages in vivo shows that it can clinically increase neutrophil counts and enhance the immune system subsequent to injuries inflicted by conditions such as myelodysplastic syndrome or injuries due to chemotherapeutic agents. In addition, considering the widespread therapeutic use of GM-CSF to boost the immune system, it can be introduced as an important agent for the treatment of dental abscesses in chemotherapy patients.
Key words: GM-CSF (granulocyte-macrophage colony-stimulating factor), Review, Therapeutic.
Journal of Isfahan Dental School
Volume 12, Issue 4 - Serial Number 4
January 2017
Pages 445-456

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