The Effect of Vitamin E Therapy on Post Chemotherapy Mucositis in Leukemic Patients
Document Type : مقالههای پژوهشی
Authors
- Pardis Parsapour 1
- Samira Shahsiah 2
- Parnian Alavinejad 2
- Shiva Iravani 3
- Zeinab Mofatteh 4
- Pardis Pedram 4
1 Department of Oral and Maxillofacial Medicine, Tehran, Iran.
2 Assistant Professor, Department of Endodontic, School of Dentistry, Ahvaz Jundishahpur University of Medical Sciences, Ahvaz, Iran.
3 Assistant Professor, Department of Endodontic, School of Dentistry, Shahrekord University of Medical Sciences, Shahrekord, Iran.
4 Dentist, Ahvaz, Iran.
Abstract
Materials & Methods: This randomized clinical trial was performed in Ahvaz’s Shafa Hospital on 56 leukemic patients, undergoing chemotherapy. The patients were divided into 3 groups: 1) systemic treatment group, case group 1; 2) topical treatment group, the case group 2; and 3) control group. The oral mucosa of the patients was evaluated for the severity of mucositis and the patient’s response to pain. Data were analyzed with Mann-Whitney test and t-test (α = 0.05).
Results: In relation to the severity of mucositis, based on the results of Mann-Whitney test, there was a significant difference between the case group 2 and control group (p value ≤ 0.01). There was no significant difference between the two case groups (p value = 0.2). In relation to the patient’s response to pain, there was a significant difference between the case group 2 and control group (p value ≤ 0.01). There was no significant difference between the two case groups (p value = 0.4). Therefore, vitamin E decreased the incidence of thermotherapy-induced mucositis.
Conclusion: Within the limitations of this study, vitamin E in its topical form is an effective medicament for reducing the severity and pain of chemotherapy-induced mucositis.
Key words: Chemotherapy, Oral mucositis, Vitamin E.
)