Journal of Isfahan Dental School

Histomorphology of Rete Ridges and their Relation to Inflammation in Oral Mucosal Lesions

Document Type : مقاله‌های پژوهشی

Authors

1 Assistant Professor, Department of Oral and Maxillofacial Pathology, School of Dentistry, Islamic Azad University Isfahan (Khorasgan) Branch, Isfahan, Iran.

2 Professor, Dental Implant Research Center, Department of Oral and Maxillofacial Pathology, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran.

3 Student, School of Dentistry, Islamic Azad University Isfahan (Khorasgan) Branch, Isfahan, Iran.

Abstract

Introduction: Rete ridges are epithelial extensions toward the underlying connective tissue in skin and mucous membranes. Given the advances in tissue engineering in recent years, rete ridges have become the center of attention. Therefore, the aim of the present study was to evaluate the shape of rete ridges (RR) in different oral mucosal lesions for possible histological differential diagnosis and their possible relation with inflammation for better understanding of their histogenesis.
Materials & Methods: This retrospective, descriptive, analytical study was performed on 154 oral lesions classified as epithelial (E), connective tissue (Ct) and mucocutaneous (Mc) lesions. RRs were evaluated under a light microscope at ×100 as flat or hyperplastic. Inflammation at epithelium‒connective tissue interface was evaluated in 5 consecutive high-power fields (×400). Data were analyzed with chi-squared test (α = 0.05).
Results: In 87%, 80% and 58% of Ct, E and Mc lesions, hyperplastic RRs were seen, respectively (p value < 0.001). RR forms Mc lesions were significantly different from the two other groups (p value < 0.001). However, no statistically significant difference was observed in RRs between E and CT lesions (p value = 0.48). Hyperplastic RRs in reactive Ct lesions was seen more frequently than other Ct lesions; however, inflammation in different intensities was not related to RR shape (p value < 0.05).
Conclusion: The results of the present study showed that rete ridges in oral mucosal lesions were hyperplastic predominantly, indicating that inflammation is not the reason for the hyperplastic nature of rete ridges. Further studies are recommended.
Key words: Epithelium, Histomorphology, Inflammation, Oral mucosa.

1. Nanci A. Ten Cate's Oral Histology: development, structure and function. 8th ed. Rio de Janeiro, Brazil: Elsevier; 2012.
2. Xiong X, Wu T, He S. Physical forces make rete ridges in oral mucosa. Med Hypotheses 2013; 81(5): 883-6.
3. Renò F, Traina V, Cannas M. Mechanical stretching modulates growth direction and MMP-9 release in human keratinocyte monolayer. Cell Adh Migr 2009; 3(3): 239-42.
4. Neville BW, Damm DD, Chi AC, BouquotJE. Oral and Maxillofacial Pathology. 4th ed. Amsterdam, Netherlands: Elsevier Health Sciences; 2015.
5. Lynch DA, Mapstone NP, Clarke AM, Jackson P, Moayyedi P, Dixon MF, et al. Correlation between epithelial cell proliferation and histological grading in gastric mucosa. J Clin Pathol 1999; 52(5): 367-71.
6. Kaplan I, Hirshberg A. The correlation between epithelial cell proliferation and inflammation in odontogenic keratocyst. Oral Oncol 2004; 40(10): 985-91.
7. Farahani SS, Navabazam A, Ashkevari FS. Comparison of mast cells count in oral reactive lesions. Pathol Res Pract 2010; 206(3): 151-5.
8. Madke B, Doshi B, Khopkar U, Dongre A. Appearances in dermatopathology: the diagnostic and the deceptive. Indian J Dermatol Venereol Leprol 2013; 79(3): 338-48.
9. Aminzadeh A, Jahanshahi G, Ahmadi M. A retrospective comparative study on clinico-pathologic features of oral lichen planus and oral lichenoid lesions. Dent Res J 2013; 10(2): 168-72.
10. Tunali-Akbay T, Solmaz Z, Pekiner FN, İpekci H. Salivary tissue factor concentration and activity in patients with oral lichen planus. Oral Science International 2017; 14(1):13-7.
11. Mizuki H, Abe R, Kogi S, Mikami T. Immunohistochemical detection of Mycoplasma salivarium in oral lichen planus tissue. J Oral Pathol Med 2017; 46(8):649-56.
12. Vujhini SK, Reddy ES, Sudheer MVS, Katikaneni HK. Irritation fibroma of tongue: a case report. International Journal of Research in Medical Sciences. Int J Res Med Sci 2016; 4(4): 1272-3.
13. Debta P, Debta FM, Bhuyan R, Siddhartha S, Goyal PK, Mohanty S. A rare histological entity- oral fibrolipoma. International Journal of Medical and Health Sciences Research 2016; 3(10): 110-14.
14. Mani A, Mhaske S, Maravar PP, Ladgive S, Kalburge JV. Peripheral ossifying fibroma. J of the Intclin Dent Res Organization 2010; 2(2): 82-5.
15. Elrahawy KMA, Nagy AI, El-Swilem RO. Fibroma of buccal mucosa: case report and literature review. European Scientific Journal 2017; 13(6): 267-72.
16. Sami M, Saito M, Muramatsu SH, Mikami T, Aleryani K, Sawair F, et al. Twin-pair rete ridge analysis: a computer-aided method for facilitating objective histopathological distinction between epithelial dysplasia and carcinoma in-situ of the oral mucosa. Oral Med Pathol 2010; 14(3): 89-96.
17. Carro OM, Evans SA, Leone CW. Effect of inflammation on the proliferation of human gingival epithelial cells in vitro. J Periodontol 1997; 68(11): 1070-5.
Journal of Isfahan Dental School
Volume 14, Issue 3 - Serial Number 3
July 2018
Pages 313-319