Document Type : مقاله‌های پژوهشی

Authors

• Farzaneh Ahrari ¹
• Masoumeh Ebrahimi ²
• Maryam Forghani ³
• Maryam Mehrabkhani ²
• Iman Parisayi ²
• Malihe Jahan Tigh ⁴
• Yeganeh Ariyan ⁵

¹ Dental Research Center, Department of Orthodontic, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.

² Dental Research Center, Department of Pediatric, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.

³ Dental Research Center, Department of Endodontics, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.

⁴ Pediatric Dentistry Specialist, Mashhad, Iran.

⁵ Graduate, School of Dentistry, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract

Introduction: This study aimed to evaluate the effect of several anticariogenic agents on preventing enamel demineralization.
Materials & Methods: In this in vitro study, 60 intact premolar teeth were selected and divided mesiodistally into two halves to provide 120 specimens. The specimens were randomly divided into 8 groups of 15 each. In groups 1 and 2, a cream containing casein phosphopeptide amorphous calcium phosphate and fluoride (MI Paste Plus), in groups 3 and 4, a cream containing hydroxyapatite and fluoride (Remin Pro), in groups 5 and 6, a sodium fluoride gel (NaF) and in groups 7 and 8, artificial saliva were used. The duration of exposure to the anticariogenic agents was 5 minutes in groups 1, 3, 5 and 7, whereas in groups 2, 4, 6 and 8, the period of exposure was 30 minutes. This procedure was performed daily for 4 days and the specimens were kept in distilled water between treatments. Then, the specimens were immersed in a demineralizing solution for 21 days. Finally, a VistaCam iX apparatus was employed to take fluorescent images from the specimens and the mineral content of the teeth was recorded. Data were analyzed with SPSS 20, using Kruskal-Wallis and Mann-Whitney U tests at a significance level of p value < 0.05.
Results: There were no significant differences in mineral contents of the teeth between the study groups at the application periods of 5 or 30 minutes (p value > 0.05). Comparison of the mineral contents of the teeth between the two application periods of 5 and 30 minutes indicated no significant differences in any of the study groups (p value > 0.05).
Conclusion: Under the conditions of this study, the effect of MI Paste Plus, Remin Pro or NaF with the application periods of 5 or 30 minutes on preventing enamel demineralization was similar to artificial saliva.
Key words: Caries, Casein phosphopeptide amorphous calcium phosphate, Demineralization, Enamel, Hydroxyapatite, Sodium fluoride.