Journal of Isfahan Dental School

Evaluation of Salivary IL6 Level in Children with Early Childhood Caries, Before and 3 Months after Treatment

Document Type : مقاله‌های پژوهشی

Authors

1 Postgraduate Student, Department of Pediatric Dentistry, School of Dentistry, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran

2 Department of Pediatric Dentistry, School of Dentistry Branch, Islamic Azad University, Isfahan, Iran

3 Department of Oral & Maxillofacial Diseases, School of Dentistry, Isfahan (Khorasgan) Branch, Islamic Azad University, Isfahan, Iran

Abstract

Introduction: To evaluate and compare salivary IL6 level in children with early childhood caries, before and 3 months after treatment.
Materials and Methods: In this study totally 32 children aged 3 to 6 years (12 without any caries, 10 with mild caries: 1 < dmft < 4, 10 with severe caries: dmft > 5) were included.
Salivary samples were taken from all children at least 1 hour after eating food. The group with severe ECC were treated as a full-mouth rehabilitation under general anesthesia. The group with mild ECC were treated in clinic. Group with no ECC followed with no treatment. 3 months after full-mouth rehabalitation, salivary samples gathered again. Data analysis was performed using Kolmogorov-Smirnov, Wilcoxon, Kruskal Wallis tests with SPSS version 22 software.
Results: Baseline IL6 was higher in patients with severe ECC (p value = 0.007 and p value = 0.001) but there was no statistically significant difference in baseline levels between first two groups. (p value = 0.059). After treatment only severe ECC group had statistically significant difference of salivary IL6 after treatment. (p value = 0.007).
Conclusion: Our findings show that salivary IL6 level could be a partial predictor of ECC lesions. Treatment in sever ECC caused statistically significant decrease in IL6 but IL6 change was not significant in mild group.
Keywords: Dental caries, Interleukin-6, Saliva

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Journal of Isfahan Dental School
Volume 16, Issue 1 - Serial Number 1
March 2020
Pages 22-30