Journal of Isfahan Dental School

Evaluation of the Frequency of Pemphigoid and Its Mucosal Manifestations in Patients with Immunobullous Lesions Referring to Isfahan Dental School and Alzahra Hospital Over an 8-Year Period from 2008 to 2016

Document Type : مقاله‌های پژوهشی

Authors

1 Professor, Dental Research Center, Department of Oral & Maxillofacial Pathology, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran

2 Assistant Professor, Dental Research Center, Department of Oral & Maxillofacial Pathology, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran

3 Dental Student, Dental School, Isfahan University of Medical Sciences, Isfahan, Iran

4 Ophthalmologist, Isfahan, Iran

Abstract

Introduction: Cicatricial pemphigoid is a type of immunobullous disease. A number of ocular manifestations can occur in these patients. Early diagnosis can be effective in preventing ocular complications. This study investigated the frequency of pemphigoid and its mucosal manifestations in patients with immunobullous lesions referring to Isfahan Dental School and Alzahra Hospital over 8 years.
Materials and Methods: In this cross-sectional descriptive/analytical study, 127 patient files of pemphigoid disease were evaluated in the Archives of the Department of Oral Diseases in Isfahan Dental School and Alzahra Hospital. The data on the age and sex of the patients were recorded. The patients were recalled and questioned about the location of the oral, cutaneous and ocular lesions, the treatment of these lesions, and the time of recovery of the lesions. All the relevant data were provided as a checklist and analyzed with SPSS 22, using ANOVA and descriptive statistical methods, including frequency distribution tables, calculation of percentages and relationships, and use of circular and bar diagrams (α = 0.05).
Results: The mean age of the patients was 64 years. There was a female predilection (2:1). Eye symptoms were more frequent in patients < 60 years of age, and ocular manifestations in patients with oral manifestations were four folds more frequent compared to patients without oral manifestations.
Conclusion: The frequency of the pemphigoid disease was 18.814%. The frequency of ocular involvement in these patients was 12.3%, with blurred vision (4.1%) being the most common problem. The relationships between ocular and oral involvement, ocular and cutaneous involvement, and the ocular involvement and age and sex were not significant.
Key words: Autoimmune diseases, Bullous pemphigoid, Benign mucosal pemphigoid, Eye manifestations, Pemphigus

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Journal of Isfahan Dental School
Volume 16, Issue 1 - Serial Number 1
March 2020
Pages 45-53