Journal of Isfahan Dental School

Clinicopathological Evaluation of Oral Pyogenic Granuloma in Isfahan School of Dentistry.

Document Type : مقاله‌های پژوهشی

Authors

1 Dental Research Center, Department of Oral and Maxillofacial Pathology, Dental Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

2 Dental Material Research Center, Department of Oral and Maxillofacial Pathology, Dental Institute, Isfahan University of Medical Sciences, Isfahan, Iran.

3 Dental Research Center, Dental Research Institute, Isfahan University of Medical Sciences, Isfahan, Iran

Abstract

Introduction: Oral pyogenic granuloma (PG) is a benign lesion that can occur due to chronic mild irritation, a traumatic surgical procedure, hormonal changes, certain medications, after bone marrow grafting, a response to a graft, etc. Two histopathological type of PG are lobular and non-lobular. This aimed to assess and compare the clinical, microscopic, and etiologic factors in the two type of PG.
Materials and Methods: In this cross-sectional descriptive/analytical study, 214 samples of PG were selected from the Archives of the Pathology Department, Isfahan Dental School. Demographic, clinical, and microscopic data were collected by reviewing the files and slides. Data were analyzed with SPSS 24, using descriptive statistics, chi-squared test, Mann-Whitney test, Fisher‘s exact test, and t-test (α = 0.05).
Results: There were 47 lobular cases, with 167 non-lobular samples. Lesion sizes (p value = 0.035), location of lesions (p value < 0.001), mean vascular density (p value < 0.001), concentration of large endothelial cells (p value < 0.001), edema (p value = 0.007), inflammatory infiltration intensity (p value < 0.001), and vascular canalization (p value = 0.005) were significantly different between the two groups.
Conclusion: The present study showed that some parameters between the two microscopic types of pyogenic granuloma were different significantly, accounting for the clinicopathological differences between two groups; this warrants further studies.
Keywords: Lobular capillary hemangioma, Oral cavity, Pyogenic granuloma

1. Krishnapillai R, Punnoose K, Angadi PV, Koneru A. Oral pyogenic granuloma--a review of 215 cases in a South Indian Teaching Hospital, Karnataka, over a period of 20 years. J Oral Maxillofac Surg 2012; 16(3): 305-9.
2. Isaza-Guzman DM, Teller-Carrero CB, Laberry-Bermúdez MP, Gonzalez-Perez LV, Tobon-Arroyave SI. Assessment of clinicopathological characteristics and immunoexpression of COX-2 and IL-10 in oral pyogenic granuloma. Arch Oral Biol 2012; 57(5): 503-12.
3. Neville BW, Damm DD, Chi AC, Allen CM. Oral and maxillofacial pathology. 4th ed. Philadelphia, PA: Elsevier Health Sciences; 2015. p. 483-4.
4. Shafer W, Hyne M, Levy B. A textbook of oral pathology. 3rd ed. Philadelphia, PA: WB Saunders; 1983. 359-61.
5. Regezi JA, Sciubba JJ, Jordan RC. Oral pathology: clinical pathologic correlations.7th ed. Philadelphia, PA: Elsevier Health Sciences; 2016. p. 118-9.
6. Gnepp DR. Diagnostic surgical pathology of the head and neck e-book. 2nd ed. Philadelphia, PA: Elsevier Health Sciences; 2009. p. 205-7.
7. Toida M, Hasegawa T, Watanabe F, Kato K, Makita H, Fujitsuka H, et al. Lobular capillary hemangioma of the oral mucosa: clinicopathological study of 43 cases with a special reference to immunohistochemical characterization of the vascular elements. Pathol Int 2003; 53(1): 1-7.
8. Epivatianos A, Antoniades D, Zaraboukas T, Zairi E, Poulopoulos A, Kiziridou A, et al. Pyogenic granuloma of the oral cavity: comparative study of its clinicopathological and immunohistochemical features. Pathol Int 2005; 55(7): 391-7.
9. Buchner A, Calderon S, Ramon Y. Localized hyperplastic lesions of the gingiva: a clinicopathological study of 302 lesions. J Periodontol 1977; 48(2): 101-4.
10. Vilmann A, Vilmann P, Vilmann H. Pyogenic granuloma: evaluation of oral conditions. Br J Oral Maxillofac Surg 1986; 24(5): 376-82.
11. Lawoyin JO, Arotiba JT, Dosumu OO. Oral pyogenic granuloma: a review of 38 cases from Ibadan, Nigeria. Br J Oral Maxillofac Surg 1997; 35(3): 185-9.
12. Al-Khateeb T, Ababneh K. Oral pyogenic granuloma in Jordanians: a retrospective analysis of 108 cases. J Oral Maxillofac Surg 2003; 61(11): 1285-8.
13. Gordon-Núñez MA, de Vasconcelos Carvalho M, Benevenuto TG, Lopes MF, Silva LM, Galvão HC. Oral pyogenic granuloma: a retrospective analysis of 293 cases in a Brazilian population. J Oral Maxillofac Surg 2010; 68(9): 2185-8.
14. Marla V, Shrestha A, Goel K, Shrestha S. The histopathological spectrum of pyogenic granuloma: a case series. Case Rep Dent 2016; 2016: 1323798.
Journal of Isfahan Dental School
Volume 16, Issue 1 - Serial Number 1
March 2020
Pages 105-113