مجله دانشکده دندان‌پزشکی اصفهان

بررسی رابطه‌ی استرس با سردرد تنشی با اندازه‌گیری آلفا آمیلاز بزاقی

نوع مقاله : مقاله‌های پژوهشی

چکیده

مقدمه: سردرد تنشی، شایع‌ترین نوع سردرد در سراسر جهان با بیشترین تأثیر اجتماعی و اقتصادی در زندگی بیمار در مقایسه با سایر سردردهای اولیه است. آلفا آمیلاز بزاقی می‌تواند تغییرات مرتبط با استرس را منعکس کند. هدف از بررسی حاضر، رابطه‌ی استرس با سردرد تنشی اپیزودیک متناوب با اندازه‌گیری سطح آلفا آمیلاز بزاق بود.
مواد و روش‌ها: در این مطالعه‌ی مورد- شاهدی، بر روی 90 نفر (45 زن مبتلا به سردرد تنشی اپیزودیک متناوب) و گروه شاهد (45 زن سالم داوطلب) انجام شد. پرسش‌نامه‌ی اضطراب همیلتون برای بررسی سطح استرس، در دو گروه تکمیل شد و سپس سطح آلفا آمیلاز بزاق اندازه‌گیری گردید. داده‌ها با استفاده از آزمون‌های آماری تی و من‌ویتنی در نرم‌افزار آماری SPSS نسخه‌ی 18 تجزیه و تحلیل شدند (0/05 = α).
یافته‌ها: میانگین سطح فعالیت آلفا آمیلاز بزاق و میانگین نمره‌ی همیلتون در گروه بیماران، به طور معنی‌داری بیشتر از این متغیرها در گروه شاهد بود (0/001 = p value). همچنین همبستگی معنی‌داری بین فعالیت آلفا آمیلاز بزاق و نمره‌ی اضطراب پرسش‌نامه‌ی همیلتون در هر دو گروه مورد (0/002 = p value) و شاهد (0/001 = p value) مشاهده شد.
نتیجه‌گیری: بر اساس نتایج این مطالعه، آلفا آمیلاز بزاقی می‌تواند یک نشانگر مناسب برای ارزیابی اضطراب در بیمار مبتلا به سردرد تنشی اپیزودیک متناوب باشد.
کلید واژه‌ها: سردرد تنشی، آلفا آمیلاز بزاقی، اضطراب.

عنوان مقاله [English]

Assessment of the Correlation between Stress and Tension-Type Headache by Measuring Salivary a-Amylase Levels

چکیده [English]

Introduction: The tension-type headache (TTH) is the most common type of headache across the world with the greatest socioeconomic impact on patient’s life in comparison with other primary headaches. Salivary α-amylase could reflect changes associated with stress in the body. The present study investigated the relationship between stress and frequent episodic tension-type headache by measuring the salivary α-amylase levels.
Materials & Methods: In this case- control study, 90 females in two groups, a case group with 45 females with frequent episodic TTH and a control group with 45 healthy females were enrolled. The Hamilton stress questionnaire was completed in the two groups to examine the level of stress. Then, salivary α-amylase levels were measured. The data were analyzed with SPSS 18 using t-test and Mann-Whitney test (α = 0.05).
Results: TThe mean salivary α-amylase activity levels and mean Hamilton questionnaire scores in the case group were significantly higher than those in the control group (p value = 0.001). In addition, there was a significant correlation between the salivary α-amylase activity and Hamilton questionnaire scores in the case (p value = 0.002) and control (p value= 0.001) groups.
Conclusion: According to the result of the present study, salivary α-amylase levels can be an appropriate marker for assessing anxiety in patients with frequent episodic tension-type headache.
Key words: Anxiety, Salivary α-amylase, Tension-type headache.

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مجله دانشکده دندان‌پزشکی اصفهان
دوره 16، شماره 2 - شماره پیاپی 2
خرداد 1399
صفحه 194-202