مواد بیواکتیو: رویکردی نوید بخش در دندان‍‌پزشکی نوین، مقاله‌ی مروری محدود

نوع مقاله : مقاله مروری

چکیده

مقدمه : مواد بیواکتیو به عنوان ماده ای تعریف می شود که بر روی بافت زنده، ارگانیسم ها و سلول یا پاسخ آن ها اثر می گذارد. این مواد در زمینه های مختلف پزشکی و دندانپزشکی استفاده می شود. خلاصه ای از کاربرد و ویژگی های این مواد عبارت اند از: استفاده در درمان پالپ کپینگ، رمینرالیزاسیون دندان به منظور بازسازی بافت سخت، خواص ضد پوسیدگی و آنتی باکتریال، برخی از این مواد داری ویژگی آلکالین ها بوده که PH اسیدی را به PH خنثی تبدیل می کنند، برخی دیگر دارای خواص ادهزیو و پیوند شیمیایی بوده، همچنین پایداری ابعادی، زیست سازگاری و بیواکتیوتی نیز از خواص آن هاست
مواد و روش ها : ما چندین مقاله (10 مقاله) را بررسی کرده و اطلاعات مورد نیاز را از داخل مقالات استخراج کرده، و در نهایت یک لیست بر اساس این اطلاعات تهیه کردیم.
یافته ها: این لیست شامل جدیدترین مواد بیواکتیو مانند بیودنتین، مواد پلیمری با ساختار نانو در ترکیب با پروتئین-رپلنت ها، همچنین مواد مشهور و معمولی که خواص بیواکتیو دارند مثل MTA ، کلسیم هیدروکساید می باشد. علاوه بر این خواص و مضرات مواد بیان شده است؛ این توضیحات کمک می کند تا در درمان های خود همه گزینه ها و مواد را شناخته و انتخاب درست تری داشته باشیم.
نتیجه گیری: مواد بیواکتیو جدید و تاثیرات آن ها می تواند باعث تحول در زمینه های مختلف دندانپزشکی شده و بسیار از مشکلات پیش رو را حل کند.
کلمات کلیدی: بیواکتیو متریال، دندانپزشکی محافظه کارانه، بازسازی، خواص مکانیکی، زیست سازگاری، خواص بیولوژیک
 

عنوان مقاله [English]

Bioactive Materials: A Promising Approach in Modern Dentistry

چکیده [English]

Introduction: Bioactive materials are known as substances that can affect living tissue, organisms and cells or their response. These materials can be used in various fields of medicine and dentistry. Today, the main use of these materials in dentistry is its use in the treatment of pulp capping, remineralization of teeth in order to restore hard tissue, and anti-caries and antibacterial properties. Some of these substances have the characteristic of alkalines, which can change acidic pH to neutral pH. Also, some others have adhesive properties and chemical bonding, and other features of these materials include their dimensional stability, biocompatibility, and bioactivity.
Materials and Method: This review was performed by searching among Persian and English sources indexed in Scopus, Pubmed, ISI, and focusing on articles published in recent years.
Results: Bioactive materials are materials such as biodentin, polymer materials with nano-structure in combination with protein-replants, as well as well-known and common materials that have bioactive properties such as (mineral trioxide aggregate), calcium hydroxide. Also, in addition to these advantages, various studies have also stated various disadvantages that should be taken into account. These explanations help us to know all the options and materials in our treatments and make a better choice.
Conclusion: Bioactive substances and their effects can cause changes in different fields of dentistry and provide new solutions to improve the materials used in dental treatments. However, more invitro and clinical studies are needed to prove the effectiveness of these materials in the dental materials syntethis.
Keywords: Adhesives, Dentistry, Anti-Bacterial Agents, Polymers

1. Anusavice KJ, Shen C, Rawls HR. Emerging trends. In: Anusavice KJ, Shen C, Rawls HR, editors. Phillip’s science of dental materials. 12th ed. ST. Louis, Missouri: Elsevier Saunders; 2012. p. 519.
2. Bhaskar SN, Beasley JD, Ward JP, Cutright DE. Human pulp capping with isobutyl cyanoacrylate. J Dent Res 1972; 51(1): 58-61.
3. Zhang N, Ma J, Melo MA, Weir MD, Bai Y, Xu HH. Protein-repellent and antibacterial dental composite to inhibit biofilms and caries. Journal of dentistry. 2015 Feb 1;43(2):225-34.
4. Chow LC. Next generation calcium phosphate-based biomaterials. Dent Mater J 2009; 28(1): 1-10.
5. Dong Q, Chow LC, Wang T, Frukhtbeyn SA, Wang F, Yang M, et al. A new bioactive polylactide-based composite with high mechanical strength. Colloids Surf a Physicochem Eng Asp 2014; 457: 256-62.
6. Chatzistavrou X, Fenno JC, Faulk D, Badylak S, Kasuga T, Boccaccini AR, et al. Fabrication and characterization of bioactive and antibacterial composites for dental applications. Acta Biomater 2014; 10(8): 3723-32.
7. Zarrabi MH, Javidi M, Jafarian AH, Joushan B. Histologic assessment of human pulp response to capping with mineral trioxide aggregate and a novel endodontic cement. J Endod 2010; 36(11): 1778-81.
8.. Zhong Y, Liu J, Li X, Yin W, He T, Hu D, et al. Effect of a novel bioactive glass-ceramic on dentinal tubule occlusion: An in vitro study. Aust Dent J 2015; 60(1): 96-103.
9. Rath SN, Brandl A, Hiller D, Hoppe A, Gbureck U, Horch RE, et al. Bioactive copper-doped glass scaffolds can stimulate endothelial cells in co-culture in combination with mesenchymal stem cells. PLoS One 2014; 9(12): e113319.
10. Chen L, Shen H, Suh BI. Bioactive dental restorative materials: A review. Am J Dent 2013; 26(4): 219-27.
11. Fernando D, Attik N, Pradelle-Plasse N, Jackson P, Grosgogeat B, Colon P. Bioactive glass for dentin remineralization: A systematic review. Mater Sci Eng C Mater Biol Appl 2017; 76: 1369-77.
12. Laurent P, Camps J, De Meo M, Dejou J, About I. Induction of specific cell responses to a Ca(3)SiO(5)-based posterior restorative material. Dent Mater 2008; 24(11): 1486-94.
13. Camilleri J, Sorrentino F, Damidot D. Investigation of the hydration and bioactivity of radiopacified tricalcium silicate cement, Biodentine and MTA Angelus. Dent Mater 2013; 29(5): 580-93.
14. Sarkar NK, Caicedo R, Ritwik P, Moiseyeva R, Kawashima I. Physiochemical basisof the biologic properties of mineral trioxide aggregate. J Endod 2005; 31(2): 97-100.
15. Torabinejad M, White DJ. Tooth filling material and use. US Patent Number 5, 769, 638; 1995.
16. Camilleri J. The chemical composition of mineral trioxide aggregate. J Conserv Dent 2008; 11(4): 141-3.
17. Parirokh M, Torabinejad M. Mineral trioxide aggregate: a comprehensive literature review--Part III: Clinical applications, drawbacks, and mechanism of action. J Endod 2010; 36(3): 400-13.
18. Schröder U. Effects of calcium hydroxide-containing pulp-capping agents on pulp cell migration, proliferation, and differentiation. J Dent Res 1985; 64(Spec No): 541-8.
19. Chandra BS, Krishna VG, editors. Vital pulp therapy, pulpotomy and apexification. In: Chandra BS, editor. Grossman’s endodontic practice. 12th ed. Gurgaon, India: Wolters Kluwer; 2010. p. 315
. 20. Addison WN, Azari F, Sørensen ES, Kaartinen MT, McKee MD. Pyrophosphate inhibits mineralization of osteoblast cultures by binding to mineral, up-regulating osteopontin, and inhibiting alkaline phosphatase activity. J Biol Chem 2007; 282(21): 15872-83.
21. Jalan AL, Warhadpande MM, Dakshindas DM. A comparison of human dental pulp response to calcium hydroxide and Biodentine as direct pulp-capping agents. J Conserv Dent 2017; 20(2): 129-33.
22. Tronstad L. Reaction of the exposed pulp to Dycal treatment. Oral Surg Oral Med Oral Pathol 1974; 38(6): 945-53.
23. Dammaschke T, Stratmann U, Wolff P, Sagheri D, Schäfer E. Direct pulp capping with mineral trioxide aggregate: An immunohistologic comparison with calcium hydroxide in rodents. J Endod 2010; 36(5): 814-9.
24. Aeinehchi M, Eslami B, Ghanbariha M, Saffar AS. Mineral trioxide aggregate (MTA) and calcium hydroxide as pulp-capping agents in human teeth: A preliminary report. Int Endod J 2003; 36(3): 225-31.
25. Accorinte Mde L, Holland R, Reis A, Bortoluzzi MC, Murata SS, Dezan E, Jr, et al. Evaluation of mineral trioxide aggregate and calcium hydroxide cement as pulp-capping agents in human teeth. J Endod 2008; 34(1): 1-6.
26. Asgary S, Eghbal MJ, Parirokh M, Torabzadeh H. Sealing ability of three commercial mineral trioxide aggregates and an experimental root-end filling material. Iran Endod J 2006; 1(3): 101-5.
27. Asgary S, Eghbal MJ, Parirokh M, Ghoddusi J, Kheirieh S, Brink F. Comparison of mineral trioxide aggregate’s composition with Portland cements and a new endodontic cement. J Endod 2009; 35(2): 243-50.
28. Yoshimine Y, Maeda K. Histologic evaluation of tetracalcium phosphate-based cement as a direct pulp-capping agent. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 1995; 79(3): 351-8.
29. Gandolfi MG, Siboni F, Prati C. Chemical-physical properties of TheraCal, a novel light-curable MTA-like material for pulp capping. Int Endod J 2012; 45(6): 571-9.
30. Zhang N, Zhang K, Xie X, Dai Z, Zhao Z, Imazato S, et al. Nanostructured polymeric materials with protein-repellent and anti-caries properties for dental applications. Nanomaterials (Basel) 2018; 8(6): 393.
31. Saha N, Saha N, Saha T, Öner ET, Brodnjak UV, Redl H, et al. Polymer based bioadhesive biomaterials for medical application-a perspective of redefining healthcare system management. Polymers (Basel) 2020; 12(12): 3015.
32. Rathi S, Saka R, Domb AJ, Khan W. Protein-based bioadhesives and bioglues. Polym Adv Technol 2018; 30(2): 217-34.
33. Palacio MLB, Bhushan B. Bioadhesion: A review of concepts and applications. Philos Trans R Soc A Math Phys Eng Sci 2012, 370(1967): 2321-47.
34. Duan W, Bian X, Bu Y. Applications of bioadhesives: a mini review. Front Bioeng Biotechnol 2021; 9: 716035.
35. Hasani-Sadrabadi MM, Sarrion P, Pouraghaei S, Chau Y, Ansari S, Li S, et al. An engineered cell-laden adhesive hydrogel promotes craniofacial bone tissue regeneration in rats. Sci Transl Med 2020; 12(534): eaay6853.
36. Jafari N, Habashi MS, Hashemi A, Shirazi R, Tanideh N, Tamadon A. Application of bioactive glasses in various dental fields. Biomater Res 2022; 26(1): 31.
37. Tabatabaei FS, Torres R, Tayebi L. Biomedical materials in dentistry. In: Tayebi L, editor. Applications of biomedical engineering in dentistry. 1st ed. Berlin/Heidelberg, Germany: Springer; 2020. p. 3-20.
38. Tai BJ, Bian Z, Jiang H, Greenspan DC, Zhong J, Clark AE, et al. Antigingivitis effect of a dentifrice containing bioactive glass (NovaMin®) particulate. J Clin Periodontol 2006; 33(2): 86-91.
39. Farooq I, Imran Z, Farooq U, Leghari A, Leghari MA. Bioactive glass: a material for the future. World J Dent 2012; 3(2): 199-201.
40. Skallevold HE, Rokaya D, Khurshid Z, Zafar MS. Bioactive glass applications in dentistry. Int J Mol Sci 2019; 20(23): 5960.
41. Felipe ME, Andrade PF, Novaes AB Jr, Grisi MF, Souza SL, Taba M Jr, et al. Potential of bioactive glass particles of different size ranges to affect bone formation in interproximal periodontal defects in dogs. J Periodontol 2009; 80(5): 808-15.
42. Lovelace TB, Mellonig JT, Meffert RM, Jones AA, Nummikoski PV, Cochran DL. Clinical evaluation of bioactive glass in the treatment of periodontal osseous defects in humans. J Periodontol 1998; 69(9): 1027-35.
43. Singh M, Mehta D. Clinical evaluation of Biogran as a graft material in the treatment of periodontal osseous defects. J Indian Soc Periodontol 2000; 3: 69-72.
44. Gholami S, Labbaf S, Baharlou Houreh A, Ting HK, Jones JR, Nasr Esfahani MH. Long term effects of bioactive glass particulates on dental pulp stem cells in vitro. Biomed Glasses 2017; 3(1): 96-103.
45. Macwan C, Deshpande A. Mineral trioxide aggregate (MTA) in dentistry: A review of literature. J Oral Res Rev 2014; 6(2): 71-4.
46. Hilton TJ. Keys to clinical success with pulp capping: a review of the literature. Oper Dent 2009; 34(5): 615-25.
47. Long Y, Liu S, Zhu L, Liang Q, Chen X, Dong Y. Evaluation of pulp response to novel bioactive glass pulp capping materials. J Endod 2017; 43(10): 1647-50.
48. Belladonna FG, Calasans-Maia MD, Novellino Alves AT, de Brito Resende RF, Souza EM, Silva EJ, et al. Biocompatibility of a self-adhesive gutta-percha-based material in subcutaneous tissue of mice. J Endod 2014; 40(11): 1869-73.
49. Mehrvarzfar P, Dahi-Taleghani A, Saghiri MA, Karamifar K, Shababi B, Behnia A. The comparison of MTA, Geristore(R) and amalgam with or without bioglass as a matrix in sealing the furcal perforations (in vitro study). Saudi Dent J 2010; 22(3): 119-24.
50. Peltola MJ, Aitasalo KMJ, Suonpää JTK, Yli-Urpo A, Laippala PJ, Forsback AP. Frontal sinus and skull bone defect obliteration with three synthetic bioactive materials. A comparative study. J Biomed Mater Res B Appl Biomater 2003; 66(1): 364-72.
51. Hench LL. Bioceramics. Am Ceram Soc Bull 1998; 81(7): 1705-1728.
52. Fetner A, Hartigan M, Low S. Periodontal repair using PerioGlas in nonhuman primates: clinical and histologic observations. Compendium 1994; 15(7): 935-8.
53. Elshahat A. Correction of craniofacial skeleton contour defects using bioactive glass particles. Egypt J Plast Reconstr Surg 2006; 30(2): 113-9.
54. Hench LL. Chronology of bioactive glass development and clinical applications. New J Glass Ceramics 2013; 3(2): 67-73.
55. Kaur G, Kumar V, Baino F, Mauro JC, Pickrell G, Evans I, et al. Mechanical properties of bioactive glasses, ceramics, glass-ceramics and composites: state-of-the-art review and future challenges. Mater Sci Eng C 2019; 104: 109895.