Frequency of Langerhans cells in oral squamous cell carcinoma with and without cervical lymph node involvement
Document Type : Original Article
Authors
1 Dentist, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
2 Associate Professor, Dental Research Center, Department of Oral and Maxillofacial Pathology, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
3 Assistant Professor, Dental Materials Research Center, Department of Oral and Maxillofacial Pathology, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract
Materials and Methods: In this descriptive-analytical, cross-sectional study that has down in Isfahan Dental Schoon in 1404, 20 OSCC samples with cervical lymph node involvement (group 1) and 20 OSCC samples without cervical lymph node involvement (group 2) were examined, registered in the archives of the Oral Pathology Department of Isfahan Dental School and Ayatollah Kashani Hospital. To determine the number of Langerhans cells, the samples were subjected to immunohistochemical staining with the CD1a. The obtained data were statistically analyzed using independent t-tests, chi-square, Mann-Whitney and Fisher's exact tests. P < 0.05 was considered significant.
Results: The mean number of Langerhans cells in group 1 was significantly lower than that in group 2 (p < 0.001). The mean number of these cells did not differ significantly in the two groups based on age, gender, tumor size, neural invasion, and histopathological grade (p < 0.05). The mean number of Langerhans cells showed a significant difference based on lymphovascular invasion and clinical stage (p < 0.001).
Conclusion: A significant decrease in the number of Langerhans cells is associated with cervical lymph node involvement. Therefore, examining these cells can be helpful in determining prognosis and determining more appropriate treatment methods.
Highlights
Laleh Maleki: PubMed, Google Scholar
Saeedeh Khalesi: PubMed, Google Scholar
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