Comparative Study of Frequency of Langerhans Cells in Oral Benign Keratosis and Epithelial Dysplasia
Document Type : Original Articles
Authors
1 Dentist, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
2 Associate Professor, Dental Research Center, Department of Oral and Maxillofacial Pathology, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
3 Associate Professor, Dental Materials Research Center, Department of Oral and Maxillofacial Pathology, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran
Abstract
Materials and Methods: In a descriptive-analytical, cross-sectional study, the present study examined 40 samples of leukoplakia, including 20 samples with histopathological diagnosis of benign keratosis (group 1) and 20 samples with epithelial dysplasia (group 2) recorded in the archives of the Oral Pathology Department of Isfahan Dental School. To determine the number of Langerhans cells, the samples were immunohistochemically stained with the CD1a marker and the number of Langerhans cells in the lesion was determined by two oral pathologists. The data obtained were statistically analyzed using independent t-tests, chi-square, Mann-Whitney, and Fisher's exact tests. P < 0.05 was considered significant.
Results: The number of Langerhans cells was significantly higher in patients diagnosed with dysplasia of the oral mucosa epithelium (38.70±14.07) than in patients diagnosed with benign keratosis (6.75±2.51) (p < 0.001), but there was no relation with age, gender, and location.
Conclusion: A significant increase in the number of langerhans cells is associated with an increased likelihood of the presence of epithelial dysplasia in leukoplakia. The results of examining these cells can help determine the prognosis and more appropriate treatment methods in patients with leukoplakia.
Highlights
Alireza Azizi: PubMed, Google Scholar
Laleh Maleki: PubMed, Google Scholar
Saeedeh Khalesi: PubMed, Google Scholar
Keywords
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