مجله دانشکده دندان‌پزشکی اصفهان

بررسی تأثیر درمان‌های پریودنتال بر مقاومت به انسولین در افراد دیابتیک مبتلا به پریودنتیت

نوع مقاله : مقاله‌های پژوهشی

چکیده

مقدمه : هدف مطالعه‌ی حاضر، بررسی تأثیر درمان غیر جراحی پریودنتال بر مقاومت به انسولین و شاخص‌های پریودنتال در افراد دیابتیک مبتلا به پریودنتیت در دانشکده‌ی دندان‌پزشکی اصفهان و مرکز پزشکی خرم در سال‌های 95-1394 بود.
مواد و روش ها: این مطالعه به صورت کارآزمایی بالینی کنترل شده یک‌سوکور بر روی 60 مراجعه‌کننده به مرکز درمانی خرم و دانشکده‌ی دندان‌پزشکی اصفهان در سال 95-1394 انجام شد. بیماران بر اساس کنترل قند خون در چهار گروه قرار گرفتند. قبل از درمان، شاخص‌های پریودنتالی اندازه‌گیری شد و میزان مقاومت به انسولین در این بیماران با کمک رزیستین بزاق تعیین گردید. پس از انجام فاز یک درمان پریودنتال و گذشت سه ماه مجدداً شاخص‌های مربوطه سنجیده شدند. در نهایت داده‌ها با استفاده از آزمون‌های آماری آنالیز واریانس یک‌طرفه Tukey's Post Hoc Test و Paired Smaples T-test، مورد تجزیه و تحلیل قرار گرفت. 0/05 = α به عنوان سطح معنی‌داری در نظر گرفته شد.
یافته ها: نتایج نشان داد، میانگین هموگلوبین گلیکوزیله، عمق پاکت، درصد نواحی دارای خونریزی و شاخص پلاک در هر 4 گروه قبل و بعد از درمان تفاوت معنی‌دار داشت (0/05 p value <)، اگرچه میانگین تغییرات این شاخص‌ها بین گروه‌ها معنی‌دارنبود (به ترتیب 45، 58، 19 و 48 درصد).
نتیجه گیری: انجام درمان‌های غیر جراحی پریودنتال باعث بهبود شاخص‌های پریودنتالی وکاهش میزان هموگلوبین گلیکوزیله و رزیستین بزاق می‌شود، ولی بین شدت دیابت و شاخص‌های ذکر شده ارتباطی دیده نشد.
کلید واژه‌ها: دیابت ملیتوس؛ پریودنتیت مزمن؛ مقاومت به انسولین؛ رزیستین

عنوان مقاله [English]

Evaluation of the Effect of Periodontal Treatments on Insulin Resistance Diabetic Patients with Periodontitis

چکیده [English]

Introduction: The purpose of present study was to evaluate the effect of periodontal treatments on insulin resistance and periodontal indices in diabetic patients with chronic periodontitis based on blood glucose control in Isfahan dental faculty in years 2015-2016.
Materials and Methods: This single blinded controlled clinical trial was conducted on 60 patients referred to Khoram treatment center and Isfahan dental faculty in 2015-16. Patients were divided into four groups based on blood sugar control.Before treatment, periodontal indices were measured, and insulin resistance was detected by measuring of salivary resisting. Then phase 1 of periodontal treatment was performed and following three months the mentioned indices were measured again. Finally, the data was analyzed with a one-way analysis of variance test, Tukey’s Post Hoc Test and paired sample t-test. The significance level was set at α = 0.05.
Results: The results showed that average of glycated hemoglobin, pocket depth, percentage of areas with bleeding and plaque index had a significant difference before and after treatment in each of the four groups p value < 0.05, although the mean changes between groups were not significant (45, 58, 19 & 48%).
Conclusion: Non-surgical periodontal treatment improves periodontal indices and reduces glycated hemoglobin and salivary resistin, however there was no association between severity of diabetes and the mentioned indices.
Key words: Diabetes mellitus; Chronic periodontitis; Insulin resistance; Resistin.

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مجله دانشکده دندان‌پزشکی اصفهان
دوره 19، شماره 2 - شماره پیاپی 2
تیر 1402
صفحه 141-150